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In addition, GLP-1 can slow gastric emptying, reduce appetite in patients and thus reduce body mass, control blood pressure, regulate blood lipids and protect cardiovascular function, and has a low risk of hypoglycemia

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Retatrutide ist der erste Triple-Agonist, der gleichzeitig an drei Inkretin-verwandte Rezeptoren bindet: den GIP-Rezeptor (GIPR), den GLP-1-Rezeptor (GLP-1R) und den Glukagon-Rezeptor (GCGR)

Clinical evidence The effectiveness of combination therapy with PIO (1530 mg daily) and tofogliflozin (TOFO 20 mg daily) for 24 weeks was investigated in 32 patients who experienced T2D and NAFLD in an open-label RCT [116]

doi: 10.1016/0014-5793(84)81114-X [DOI] [PubMed] [Google Scholar] 17

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