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Experiment 1: Semaglutide Sixteen rats (7 males and 9 females) were initially assigned in a counterbalanced manner to one of four treatment conditions: 0, 0.01, 0.03, or 0.1 mg/kg semaglutide

Patients should be reassured that regulatory authorities continue to prioritise medication safety whilst recognising the substantial benefits these medicines offer for metabolic health

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Semaglutide also modulates appetite suppression, energy expenditure and satiety signaling through its binding to GLP-1R in the hypothalamus (e.g., arcuate nucleus) [79]
Gastrointestinal losses combined with reduced food and fluid intake can deplete sodium, potassium, magnesium, and chloride, affecting cardiac rhythm, muscle function, and cellular metabolism
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