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The honest summary of the structural picture is that orforglipron is not simply a small version of semaglutide. It is a chemically unrelated molecule that activates the same receptor through a partly different binding mode, exploiting a pocket the peptide barely touches and depending on a primate-specific residue the peptide does not require

That information helps the reviewing clinician make an appropriate determination

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What does the clinical evidence say about GLP-1 and gastrointestinal side effects

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