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Nursing Considerations: Administer via a central venous line if possible to prevent phlebitis

Projected retatrutide timeline (based on these patterns) Phase 3 trials began: 2024 (TRIUMPH program) Expected FDA submission: 2026-2027 Expected FDA approval: 2027-2028 Expected commercial availability: 2028 Expected stable widespread availability: 2029-2030 (assuming manufacturing ramp-up and shortage resolution) Key lesson from prior launches Demand for GLP-1 medications has consistently exceeded manufacturer projections

Danish Novo Nordisk A/S has presented preliminary Phase III data from a two-part pivotal study in 1,200 adults with metabolic dysfunction-associated steatohepatitis (MASH) and moderate to advanced liver fibrosis (stage 2 or 3)

Runners who lose 810 pounds on Ozempic often run slower, not faster, because the reduction in power-to-weight ratio is outweighed by impaired fuel availability

Drummond RF, Seif KE, Reece EA

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