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GLP-1R knockout mice exhibit reduced responses to sweeteners, confirming their key role in sweet perception, as well as increased sensitivity to monosodium glutamate (MSG), suggesting GLP-1 may inhibit umami taste as well (65)

Understanding these effects, both beneficial and adverse, is essential for optimizing treatment outcomes and minimizing risks

[9, 20, 24, 25, 19] discussed the rationale for participant selection and provided justification for their sample sizes

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