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Conclusions Semaglutide 2.4 mg was cost-effective compared to D&E alone for patients with obesity (BMI30 kg/m2) and weight related comorbidities in Portugal, over a 40-year time horizon.

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Appetite shifts typically begin within the first 1 to 2 weeks

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Sermorelin and tirzepatide serve distinct physiologic roles: sermorelin stimulates growth hormone, while tirzepatide targets appetite and glucose metabolism

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These benefits are particularly notable in patients with coexisting metabolic conditions

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