tirzepatide and anaesthesia Anesthetic Considerations for Patients Taking Glucagon-Like Peptide-1 Agonists Perioperative management of patients taking

In the SURPASS clinical trial program in type 2 diabetes mellitus (T2D), tirzepatide was associated with unprecedented reductions in HbA1c, clinically significant weight loss and other metabolic benefits, combined with low rates of hypoglycaemia across a wide range of patient characteristics

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The glucagon-like peptide-1 receptor (GLP-1R) regulates insulin secretion, carbohydrate metabolism and appetite, and is an important target for treatment of type II diabetes and obesity

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Tirzepatide has shown sustained safety in clinical trials lasting over two years, with ongoing research supporting extended use for chronic weight management