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Early Response Indicators: Early reductions in fasting serum glucose [8] and body weight with tirzepatide were associated with better long-term metabolic outcomes, suggesting that early response may inform treatment individualization

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Glucagon receptor activation increases energy expenditure directly, potentially offsetting some of the adaptive thermogenesis that drives stalls on other GLP-1 medications

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injections of 100 nmol kg 1 MK-801, 100 nmol kg 1 GLP-1, 100 nmol kg 1 GLP-1MK-801 or vehicle (isotonic saline) for 3 days