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* Evidence Strength Grading: Medium to High indicates evidence from post-hoc analyses of major RCTs combined with large-scale retrospective studies, though findings may show some nuances (e.g., early worsening vs

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However, it must be stressed that, despite the lack of reproductive improvement, even low doses of GLP1/E were sufficient to markedly improve the metabolic perturbations in PWA mice, thus defining an optimal scenario for occasions in which the main therapeutic objective would be metabolic normalization rather than reproductive rescue, as is actually the case for most women with PCOS, without pregnancy desire, which are submitted to continued hormonal contraception plus metformin treatment

Many patients also notice psychological shifts: reduced food noise, clearer eating habits, and sustainable portions that feel natural rather than restrictive