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However, due to their efficacy in inducing body-weight loss, extensive evidence with high doses of GLP-1R agonists have demonstrated clinically relevant and sustained effects on body weight in obesity [26]

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Mitic, B., Lazarevic, G., Vlahovic, P., Rajic, M

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History of pancreatitis or gallbladder disease: Use is discouraged because these medications can increase risk

Consequently, this prolongs the feeling of fullness (satiety), reduces appetite, and reduces overall calorie intake subsequently leading to negative energy balance and weight loss 18