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Licensed compounding pharmacies make these products, which are not FDA-approved

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Some patients unconsciously increase portion sizes after a few weeks because they've adapted to the suppressed appetite sensation, or they switch to high-calorie liquid foods that bypass satiety signals

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Even though this phenomenon has not been fully understood in the context of the possible exacerbation of pro-depressive changes by GLP-1RA administration, it certainly requires careful investigation before the potential introduction of these compounds to the clinic for the treatment of mood disorders in the future