compound glp 1 vs wegovy Compounded semaglutide vs. Diabetes advocacy group discourages use

Description

McGraw-Hill / Lange rxlist.com (Trulicity ) Semaglutide Drug Names : Ozempic (for T2DM) - injectable Wegovy (for weight management) - injectable Rybelsus (oral) - 1st oral GLP-1 agonist (FDA approved 9/20/19) Drug Category : GLP-1 receptor agonist, hypoglycemic Synthetic peptide analog of GLP-1 Mechanism of Action: Synthetic peptide that is chemically identical to GLP-1, except for three amino acid substitutions and modifications at positions 8, 26 & 34 (Figure 1) that prevent chemical breakdown by DPP-4, and increase binding to albumin

[DOI] [PubMed] [Google Scholar] 12.Sreedharan N., Mahadev R., Sonal Sekhar M

So I think for some patients, some populations, having data, having the evidence generated that supports that these therapies are helpful for their asthma will enable them to sort of maybe preferentially go on or use that therapy for their diabetes or for weight loss, Cahill said

For the CagriSema combination, gastrointestinal adverse events affected 79.6% of participants compared to 39.9% with placebo

A rapid escalation is associated with low blood sugar levels and severe GI side effects such as severe abdominal pain, nausea, vomiting, and inflammation of the pancreas (pancreatitis)