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As awareness grows, more patients are likely to seek these treatments

Heres what to ask before you start
A meta-analysis involving more than 70,000 participants with type 2 diabetes (SMART-C) found that the cardiovascular benefits of SGLT-2 inhibitors, including reductions in MACE, cardiovascular death, hospitalisation for HF, and CKD progression, were consistent regardless of whether patients were receiving a GLP-1 receptor agonist at baseline [19]

Yeshowever, this is not a dieting program
Mitochondrial dysfunction is a central feature of PD pathogenesis, especially through interference with Complex I and Complex II of the electron transport chain (ETC)

TNF dephosphorylates FoxO1, which is then translocated directly to the nucleus, negatively inhibiting the LEPR promoter and inducing leptin resistance
