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The main activity of DPP4 is to remove N-terminal dipeptides from polypeptides (Reference Thoma, Lffler and Stihle18) , which preferably have a proline or alanine in the second position from the N-terminal

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In 18 FDG-PET brain scans, the placebo group deteriorated, while the high-insulin drug group did not

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The higher tirzepatide doses of 10 and 15 mg were noninferior compared to insulin glargine for the change in HbA1c (primary endpoint)