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In 2020 the first small-molecule structure (Zhao et al) revealed a druggable transmembrane sub-pocket distinct from the peptide-binding interface

[DOI] [PMC free article] [PubMed] [Google Scholar] 153.Parker J.A., McCullough K.A., Field B.C., Minnion J.S., Martin N.M., Ghatei M.A., Bloom S.R