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Intranasal delivery of glucagon-like peptide-1 to the brain for obesity treatment: opportunities and challenges

The overall RR for this HbA1c target goal achievement was 2.45 (95% CI 1.95, 3.10

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67,68 Still, the presence of GLP-1 RA-specific psychiatric adverse events that may also be related to drug intolerance requires the development of a strategy to overcome this barrier for the better implementation of GLP-1RA therapy

Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes: Meta-analysis