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Acknowledgements The authors would like to thank Thomas Rohban, MD, and Magalie El Hajj, PharmD, from Partner 4 Health (Paris, France) for providing medical writing support in accordance with Good Publication Practice (GPP3) guidelines

4 Hyperandrogenism, ovulatory function, and fertility outcomes: a reproductive perspective 4.1 Remodeling of the androgen profile and endocrine homeostasis Hyperandrogenism is a hallmark phenotype of PCOS, serving as the link between metabolic derangement and ovulatory dysfunction via the insulinovaryhepatic SHBG axis

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Theres always been the question, Could we get leptin to work? Drucker said

doi: 10.1016/j.cmet.2017.08.004