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Figure 2 Consequential due to its short half-life, native GLP-1 has only limited pharmacological potential and only ~1015% of active GLP-1 is estimated to reach the general circulation (59, 6668)

Sharing this information with your doctor may help you avoid possible interactions

DeLawter, D, Winship, T 1963

GLP-1 interacts with L 142 , L 145 , and Y 152 , whereas, SR18 interacts with L 141 , L 142 , L 145 , and I 146 of GLP-1R

For many patients, this disruption manifests as pancreatitis during the adjustment period

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