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Creatinine rising above reference ranges suggests reduced kidney function

The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis

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References: Semeco A

In the mesolimbic system, GLP-1R activation has been shown to attenuate the rewarding effects of palatable food and addictive substances, indicating potential therapeutic applications for GLP-1R agonists in treating obesity and SUDs [19,20,21]