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These cytokines activate the nuclear factor kappa-B (NF-B) signaling pathway,inducing the upregulation of apoptotic proteins and matrix-degrading enzymes, such as metalloproteinases (MMPs), which irreversibly degrade the extracellular matrix (ECM) 6,7

During low-oxygen conditions, cells adapt to hypoxic stress by increasing the HIFs expression, which regulates metabolic processes and energy metabolism [43]
to qualify, patients must be adults with a BMI of at least 35 kg/m, prediabetes and an elevated risk of cardiovascular disease

Focus on complex carbohydrates like whole grains, fruits, and vegetables, which provide sustained energy and help manage blood sugar
