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Some researchers prefer evening injections because they can sleep through the initial hours when nausea peaks

A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient

2019 Mar 4;21(5)

.10.1007/s13679-017-0262-y [DOI] [PMC free article] [PubMed] [Google Scholar] 24.Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MT, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF, STEP 1 Study Group Once-weekly semaglutide in adults with overweight or obesity
