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Remove one, and the ecosystem breaks down

The SELECT trial demonstrated that semaglutide 2.4 mg reduced major adverse cardiovascular events (heart attack, stroke, and cardiovascular death) by 20% in adults with overweight or obesity and established heart disease (Lincoff et al., SELECT trial, New England Journal of Medicine , 2023)

Potential mental health benefits Reduced food noise and cognitive load Many individuals describe a quieting of constant food-related thoughts

Each receptor contributes differently to the overall effect, and each activates at different dose thresholds

Glucagon-like peptide-1 receptor agonists in the perioperative period: implications for the anaesthesiologist

Side effect management : Some patients experience nausea, usually mild and transient