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Beyond energy production, some research suggests creatine may also influence: Muscle protein synthesis , via anabolic signalling pathways though evidence in this area is heterogeneous and requires further investigation Cell hydration , as creatine draws water into muscle cells, contributing to cell volumisation Satellite cell activity , which may play a role in muscle repair and growth though this remains an area of ongoing research Individuals with low dietary creatine intake including vegetarians and vegans tend to have lower baseline muscle creatine stores and may therefore experience a more pronounced response to supplementation

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First, taking berberine with food reduces GI irritation significantly

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