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If you are in the titration phasemeaning your dose is currently being increased every four weeksbe extra cautious, as your body is already working hard to adapt to higher levels of the medication
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In a subanalysis of the SELECT trial, adults with overweight or obesity plus CVD but without diabetes had a 22% lower risk for a 5-component kidney composite endpoint if they received semaglutide 2.4 mg (Wegovy, Novo Nordisk) vs

BMJ 29:372:n71

Oleate increase neutral lipid accumulation, cellular respiration and rescues palmitate-exposed GLP-1 secreting cells by reducing ceramide-induced ROS

This is why its so important to understand the effects of this new class of drugs on it. In their review of the available medical literature, the researchers found that GLP-1 drugs improve certain measures of heart function, yet those improvements dont translate into significant improvements in VO 2 max
