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As diabetes is a major risk factor for CKD [67], specialized expert groups such as the Kidney Disease: Improving Global Outcomes (KDIGO) team, with the endorsement of both ADA and EASD, recommend that glycemic management for T2D patients with CKD should involve a combination of metformin and a SGLT-2 inhibitor as first-line therapy, with other drugs such as SUs considered only when additional therapies are needed for optimum glycemic control [68]
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In mice, evidence points to chemogenetic stimulation of Glp1r+ vagal afferents to induce a transient inhibition of AgRP neuron activity in the arcuate nucleus to directly promote satiety [82]
thetaiotaomicron led to a 25.17% reduction in GLP-1 levels but failed to restore locomotion (Supplementary Fig
