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[2] [7] These findings led regulatory authorities, including the Medicines and Healthcare products Regulatory Agency (MHRA) and the European Medicines Agency (EMA), to include specific warnings and precautions in the prescribing information for all GLP-1 medications

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Outcomes were retrieved from different real-world databases in VID (primary care electronic records, in-hospital and outpatient hospital records and emergency room records), via ICD codes registered during healthcare encounters (see ESM Table 1)

Activation of GLP-1R, a G s -coupled GPCR, increased cAMP concentrations in rat NG neurons and enhanced their excitability by suppressing potassium currents and enhancing membrane depolarization, thereby increasing intracellular calcium 41,42

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