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Behavioral Shifts: Helping patients recognize head hunger versus physiological hunger

Gradual taper of dose The Approach For patients who want to find the lowest effective dose or to discontinue completely, a gradual taper means stepping the GLP-1 dose down in small, planned increments (typically using the same titration steps as initiation, but in reverse) to test whether benefit can be maintained with less medication or none at all

To become a "blockbuster," it must meet efficacy (big mean body weight loss), tolerability (fewer side effects), and something unique, such as dosing convenience (oral delivery and once-a-month shot)

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The American Journal of Gastroenterology

However, the long-term use of insulin has been associated with insulin desensitization, decreasing the effectiveness of insulin