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A novel approach to treating opioid use disorders: Dual agonists of glucagon-like peptide-1 receptors and neuropeptide Y2 receptors

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These two events are mechanistically separable: extracellular domain binding affinity does not predict transmembrane domain activation efficiency, and mutations in the extracellular domain can selectively abolish -arrestin recruitment while preserving cAMP production

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Int J Obes (1981) 5(5):47180

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