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Compared to those receiving neither medication, all-cause mortality was significantly lower among patients treated with SGLT2-I only (HR 0.28, 95% CI 0.270.29), GLP-1RA only (HR 0.39, 95% CI 0.370.40) and both agents (HR 0.17, 95% CI 0.160.18)

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A recently published, randomized, placebo-controlled trial found a greater reduction in BMI z-score (0.22 SDs) in adolescents receiving liraglutide compared with placebo

Patients must transition to FDA-approved meds, impacting cost and availability.