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1c,f), GLP-1RA/tesaglitazar showed a delayed onset of PPAR/RXR heterodimerization with comparable potency relative to tesaglitazar after 30 min when tested in GLP-1R expressing HEK293 cells (Fig

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(PDF) Chen, X., Fan, X., Hu, Y., Zuo, C., Gabrieli, S., Holt, D., Gong, Q., Yang, Y., Pizzagalli, D.A., Du, F., Ongur, D

A phase 4 trial (NCT05181475) was initiated in December 2021 to examine the long-term efficacy and safety of GV-971 as well as changes in blood and gut microbiota biomarkers and thereby validate its mechanism of action and establish guidance for the more rational use of drugs in clinical practice