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Description
Fasting blood glucose levels often improve first, followed by reductions in post-prandial (after-meal) glucose excursions as gastric emptying slows

Less food also opens the door for protein and vitamin deficiencies

This positions Orforglipron as a strong oral competitor to injectable GLP-1 drugs like Wegovy and Zepbound

The clinical effects of berberine and GLP-1 agonists also differ substantially

"It sounds like an easier, cheaper pathway

Phase 3 trials are ongoing, and without completed large-scale safety and efficacy data, the compound cannot be considered ready for routine clinical use