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What the 2025 Gastroenterology Metaanalysis Found The systematic review and metaanalysis (DOI: 10.1053/j.gastro.2025.06.003) evaluated safety outcomes across randomized trials and realworld studies of GLP1 RAs

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However, it also turns out that interaction of GLP-1 agonists with receptors found on brain cells leads to feelings of satiety and reduced hunger

Adults with type 2 diabetes assigned an SGLT2 inhibitor or a GLP-1 receptor agonist during cardiovascular outcomes trials derived benefit from the therapies regardless of whether they were prescribed insulin, according to a meta-analysis.In an analysis of data across eight large, multiyear CV outcomes trials for three classes of diabetes agents, researchers also found that participants using