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l-valine is a powerful stimulator of GLP-1 release in rodents

The best results happen when the medicine is used along with healthy eating and exercise, and people may gain weight back if they stop taking the medicine

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Purpose of Review: This article summarizes the medical management of obesity with an emphasis on incretin-based therapeutics that target the neuro-hormonal basis of obesity.Recent Findings: Medications that mimic the effect of incretins, a group of peptide hormones released in response to nutrient intake that regulate appetite, result in potent and durable weight loss

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