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The E-values were notably high, at 4.51 for all-cause mortality, 2.38 for MACEs, and 2.00 for MAKEs, indicating that the observed associations are unlikely to be explained away by potential confounding (Supplemental Table 7)

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Reviewing the COA yourself, or confirming the pharmacy has a strict protocol for doing so, is a powerful way to ensure you are partnering with a responsible compounding pharmacy

Although not definitively proven, this risk has been a significant concern, particularly with long-term use

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Others may be due to the play of chance or bias, because of differences between patient groups who are chosen to start different diabetes medications