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Conflict of interest Andr J

As research continues, long-term safety data across broader populations are still emerging

Moreover, several second-generation medicines shown substantial cardiovascular advantages in extensive outcome studies, therefore enhancing their therapeutic efficacy beyond basic glucose regulation (Nauck and Meier 2019)

Analysis of proglucagon synthesis and secretion in rare enteroendocrine L cell populations in the small and large bowel is also technically challenging

GIP also plays important roles in fat metabolism

This experiment more comprehensively revealed the mechanism of berberine acting on GLP-1/GLP-1R/PKA signal pathway, and also showed that islet cell probably play an important role in the treatment of T2DM, providing some ideas for the follow-up study of islet function