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This effect is also observed after specific activation of GLP-1R in the NAc and most likely those receptors located on medium spiny neurons that express the dopamine-D1 receptors or dopamine-D2 receptors (Zhang et al., 2020)
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GLP-1 Diabetes and Weight Loss
(Lond.) 45 , 235246 (2021)
The importance of SCFA-mediated GLP-1 secretion is highlighted by the observation that FFAR2 knockout mice exhibit reduced insulin levels and impaired glucose tolerance due to reduced GLP-1 levels (24)
