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Switching to Zepbound may offer renewed therapeutic benefits and improve weight management outcomes

While lifestyle modifications remain very important, anti-diabetic medications such as pioglitazone, GLP-1 RAs, the dual GLP-1/GIP RA tirzepatide and SGLT-2i have demonstrated benefits in improving liver parameters and slowing disease progression

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The Precision Peptide Genetic Test identifies variants in the GLP1R gene (rs6923761) and 13 other peptide pathways affecting medication sensitivity and metabolic response

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14 However, the Urban Institute researchers included North Carolina as a state where the EHB benchmark plan covers pharmacology for weight loss because some anti-obesity medications (e.g