glp 1 age restrictions Indications for GLP-1/GIP RA Summary Sheet and Beyond! TrimRX | GLP-1 Medications After

So, patients should stick to their providers and see their availability of these drugs

Key Takeaways Triple agonist mechanism: Retatrutide is the first medication to activate GIP, GLP-1, and glucagon receptors simultaneously GLP-1 component reduces appetite and slows gastric emptying, the core appetite suppression pathway GIP component improves insulin sensitivity and promotes favorable fat distribution Glucagon component increases energy expenditure through thermogenesis and promotes fat breakdown Weight loss: Phase 2 trials showed up to 24.2% weight loss at 48 weeks, compared to tirzepatide (~22%) and semaglutide (~15%) Investigational status: Not FDA-approved

Kishi T, Hirooka Y, Sunagawa K

This chapter reviews the effects of GLP-1-related drugs used in treatment of diabetes or obesity on gastric motor functions, chiefly gastric emptying

Stenblom EL, Egecioglu E, Landin-Olsson M, Erlanson-Albertsson C

doi: 10.1111/bph.v174.7 20 ZhuBGongNFanHPengCSDingXJJiangYet al