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GLP-1s can influence all three

By enhancing insulin secretion and reducing the release of glucagon, semaglutide helps to stabilize blood sugar levels, reducing the risk of hyperglycemia and the complications associated with diabetes

It is a triple agonist, adding glucagon receptor activation to the mix, and that third receptor changes everything from thermogenesis to liver fat metabolism to the total percentage of body weight people lose in controlled studies

The theory is straightforward

doi: 10.3389/fendo.2018.00754 Received 31 October 2018 Accepted 27 November 2018 Published 04 January 2019 Volume 9 - 2018 Edited by Maximilian Bielohuby, Sanofi, France Reviewed by Yoshio Fujitani, Gunma University, Japan

It disrupts the balance between muscle protein synthesis and degradation [36], resulting in net muscle loss