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Discontinuation was common: 54.2% of the patients in the study data discontinued their GLP-1 RA (30 days without medication on hand), highlighting the need for additional research on the role of shortages, adverse events, and costs
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*Eligible patients without diabetes but with a BMI of 30, or 27 with comorbidities, lost an average of 21% of their body weight (-48 lbs) in a 72-week clinical trial evaluating 15 mg of tirzepatide, when combined with a reduced-calorie diet and increased physical activity
If symptoms are severe such as fever, rigors, or back pain seek same-day medical assessment, as these may indicate a kidney infection
Correction of permeability with pore radius of tight junctions in Caco-2 monolayers improves the prediction of the dose fraction of hydrophilic drugs absorbed by humans
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