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Abbreviations CVE: Cardiovascular event EHR: Electronic health record GLP-1RA: Glucagon-like peptide-1 receptor agonist MACE: Major adverse cardiovascular events NAFLD: Non-alcoholic fatty liver disease NASH: Non-alcoholic steatohepatitis PCI: Percutaneous coronary intervention PSM: Propensity score matching SGLT2: Sodiumglucose cotransporter 2 SMD: Standardised mean difference TG: Triacylglycerol References Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M (2016) Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes

Anstey KJ, Ee N, Eramudugolla R, Jagger C, Peters R

Elevated cAMP acts mainly through the following molecular pathways: inhibition of the ERK pathway, activation of the PKA-AMPK-mTOR pathway, and activation of the p38 signaling pathway [13, 17, 56,57,58]: first, it inhibits the extracellular signal-regulated kinase (ERK) pathway, decreasing its activation of cyclin D1, thereby hindering cyclin D1-mediated DNA replication initiation and transition into the S phase of the cell cycle [17]

doi: 10.1186/1742-2094-9-276 10 NauckMAQuastDRWefersJMeierJJ

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Still, the estimated K d value derived for EP45 from this dose-response analysis was 47 nM (Fig