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And they stayed on protocol because the gradual starting dose made the journey tolerable

Nolte Kennedy MS (2012): Pancreatic Hormones & Antidiabetic Drugs (Chapter 41)

Overall, 8891% of patients preferred the profile of oral semaglutide versus dulaglutide [91]

While the close relation between GLP-1 and insulin signalling is undoubtedly important in cognition, it is crucial to highlight that beyond this mechanism, GLP-1R mimetics upregulated several neuroprotective growth factors such as: insulin-like growth factor 1 (IGF-1) (165), brain-derived neurotrophic factor (BDNF) (166), glia-derived neurotrophic factor (GDNF) (164), as well as vascular endothelial growth factor (VEGF) (157, 158)
Diabetes, Obesity and Metabolism, 23(8), 18341842

Pharmacol Rev (2008) 60:470512
