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The absolute number of DVT events across all 21 trials was small, which is exactly why the confidence interval stretches so wide, from 1.09 to 12.25

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25 Concerns regarding the validity of outcomes have emerged, particularly owing to the reliance on indirect indicators such as the calcitonin test, carcinoembryonic antigen measurement, or vandetanib treatment to distinguish between MTC and non-MTC

doi: 10.2337/dc25-1840

Metabolites within the gut play a crucial role in mediating interactions between microbiota and the host, contributing to intestinal homeostasis

These medications have undergone rigorous clinical trials demonstrating safety and efficacy for their FDA-approved indications