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The molecular pathways that drive increases in cell mass have been widely studied
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However, when these mice are placed on a high-fat diet (HFD) the Glp1r/ animals are leaner than wild-type (WT) controls (Hansotia et al., 2013), a phenotype that goes against the role of GLP-1R signaling in the control of body weight

J Clin Invest 63(2):230238

A major class of spinal afferent endings, identified as intraganglionic varicose endings, has been found within myenteric ganglia of both the stomach and colon