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2023 May 23;14:1181913

The search for an ideal drug or Holy Grail within this landscape of possible agents continues, as weight reduction is achieved only in less than 10% of patients

Lipid handling in the intestine is important for maintaining energy homeostasis and overall health
NAD+ supports cellular repair, mitochondrial efficiency, and energy production, while Tirzepatide improves appetite control and insulin signaling

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The new challenge: smaller appetite, higher protein needs GLP-1 medications help with weight loss by increasing satiety and slowing gastric emptying
