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Since muscles contribute to energy expenditure at more than twice the rate of fat tissue, the reduction in muscle and other lean mass accompanying fat loss results in lower energy expenditure after weight reduction

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Can J Diabetes (2014) 38(5):36471.10.1016/j.jcjd.2014.05.001 67 KrasnerNMIdoYRudermanNBCacicedoJM

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Both rely on consistent gastric pH and intestinal absorption for efficacy

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