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Mario's right on target with that

Who Should Consider Oral GLP-1 Options Despite lower effectiveness, oral semaglutide makes sense for a specific subset of patients

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Additionally, GLP-1 receptors in the brainstem's area postrema, a region involved in detecting toxins and triggering the vomiting reflex, may contribute to nausea when activated

Psychiatry 23 , 11571168

Biased GLP-1 Agonists: Researchers are exploring GLP-1 agonists with biased signalling profiles that may offer improved efficacy and tolerability