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Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes In patients with preexisting cardiovascular disease and overweight or obesity but without diabetes, weekly subcutaneous semaglutide at a dose of 2.4 mg was superior to placebo in reducing the incidence of
Why this duo (benefits that matter)
GLP-1s have much more long term safety data although have the undesirable side effect of sarcopenia (loss of muscle mass)
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Conclusion GLP-1 RAs may significantly lower the combined risk of mortality and hospitalization in patients with HFpEF
