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Heavy alcohol use is also a risk factor for lactic acidosis with metformin

11 In the active-controlled trials that evaluated semaglutide as an add-on to 1 to 2 OADs (PIONEER 2 to 4), the proportion of patients that experienced at least 1 AE was ranged from 67% to 83% across treatment groups over 52 to 78 weeks

Further, if a patient received a prescription for an alternative drug due to the shortage, we did not capture that here

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[13] [14] For medicines with a narrow therapeutic index, consider appropriate spacing of doses and additional monitoring

However, these tend to be dosage-dependent