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Donors should also report any recent dose escalations and current symptoms, as these may affect eligibility decisions at some centers

At 48 weeks, mean percentage changes in body weight from baseline were approximately: In the 12 mg arm, roughly 100% of participants achieved at least 5% body-weight loss, about 83% reached 15% loss, around 63% achieved 20% loss, and approximately 26% crossed the 25% threshold

The abundance of Prevotella copri was positively correlated to blood concentrations of interferon gamma and lipopolysaccharide in T2D patients (51)

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Nonetheless, the magnitude of weight loss observed particularly at the 8 mg and 12 mg doses was described by the investigators as among the most substantial reported in a pharmacological obesity trial to date

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